MID: A Self-Supervised Multimodal Iterative Denoising Framework

Denoising is important in many vision, medical, and biological applications, yet real observations are often corrupted by complex nonlinear noise and clean targets are often unavailable. We present MID, a self-supervised iterative denoising framework across data modalities. MID treats an observation as an intermediate state along a controllable corruption process and learns from noisy data only through two networks: a step predictor that estimates the current corruption stage and a residual predictor that estimates the effective residual increment to be removed at that stage. For nonlinear corruption, MID uses a first-order local approximation to enable iterative restoration in a locally linear regime. The same formulation can be instantiated with modality-specific backbones for images, signals, point sets, and sequences. Experiments on diverse tasks in computer vision, biomedicine, and bioinformatics show that MID is robust, broadly applicable, and competitive with recent baselines.