MergeSlide: Continual Model Merging and Task-to-Class Prompt-Aligned Inference for Lifelong Learning on Whole Slide Images

Lifelong learning on Whole Slide Images (WSIs) aims to train or fine-tune a unified model sequentially on cancer-related tasks, reducing the resources and effort required for data transfer and processing, especially given the gigabyte-scale size of WSIs. In this paper, we introduce MergeSlide, a simple yet effective framework that treats lifelong learning as a model-merging problem by leveraging a vision–language pathology foundation model. When a new task arrives, it is ❶ defined with class-aware prompts, ❷ fine-tuned for a few epochs in a classifier-free manner, and ❸ merged into a unified model using an orthogonal continual-merging strategy that preserves performance and mitigates catastrophic forgetting. For inference under the class-incremental learning (CLASS-IL) setting, where task identity is unknown, we introduce Task-to-Class Prompt-aligned (TCP) inference. Specifically, TCP first identifies the most relevant task using task-level prompts and then applies the corresponding class-aware prompts to generate predictions. To evaluate MergeSlide, we conduct experiments on a stream of six TCGA datasets. The results show that MergeSlide outperforms both rehearsal-based continual learning and vision-language zero-shot baselines. Code and data are available at https://github.com/caodoanh2001/MergeSlide.