FSP-DETR: Few-Shot Prototypical Parasitic Ova Detection

Object detection in biomedical settings is fundamentally constrained by the scarcity of labeled data and the frequent emergence of novel or rare categories. We present FSP-DETR, a unified detection framework that enables robust few-shot detection, open-set recognition, and generalization to unseen biomedical tasks within a single model. Built upon a class-agnostic DETR backbone, our approach constructs class prototypes from original support images and learns an embedding space using augmented views and a lightweight transformer decoder. Training jointly optimizes a prototype matching loss, an alignment-based separation loss, and a KL divergence regularization to improve discriminative feature learning and calibration under scarce supervision. Unlike prior work that tackles these tasks in isolation, FSP-DETR enables inference-time flexibility to support unseen class recognition, background rejection, and cross-task adaptation without retraining. We also introduce a new ova species detection benchmark with 20 parasite classes and establish standardized evaluation protocols. Extensive experiments across ova, blood cell, and malaria detection tasks demonstrate that FSP-DETR significantly outperforms prior few-shot and prototype-based detectors, especially in low-shot and open-set scenarios.