Reframing Osteoarthritis Therapy Through the Gut– GUDCA – FXR – GLP1 Pathway: Opportunities and Limitations
Abstract
Recent advances in immunometabolism and rheumatology have highlighted the role of gut-derived signals in modulating joint health.In particular, Yang et al. proposed that osteoarthritis (OA) may be influenced by intestinal bile acid metabolism through a mechanistic cascade involving the gut microbiota, Glycoursodeoxycholic acid (GUDCA), intestinal Farnesoid X receptor (FXR), and Glucagon-like peptide 1 (GLP-1) signaling.This emerging gut-to-joint communication axis invites new thinking about the pathogenesis and treatment of rheumatic diseases.
Fields of Study & Subjects
Drug Transport and Resistance Mechanisms
Gut microbiota and health
Rheumatoid Arthritis Research and Therapies
Publication details
- Journal / source
- International Journal of Rheumatic Diseases
- Volume
- 29
- Issue
- 1
- Pages
- e70535–e70535
- Publication date
- 1 January 2026
- Language
- EN