Glucagon‐like peptide‐1 receptor agonists in alcohol use disorder: Multi‐system effects, early clinical promise and uncertain long‐term use
Abstract
Glucagon-like peptide-1 receptor agonists in alcohol use disorder: Multi-system effects, early clinical promise and uncertain long-term use GLP-1 receptor agonists (GLP-1RAs) are multi-system modulators currently being investigated for their potential in treating alcohol use disorder (AUD).While originally developed for metabolic disorders, serendipitous clinical observations and pre-clinical data suggest these agents may modulate both central reward processing and peripheral physiological pathways.This dual mechanism positions GLP-1RAs as a promising candidate to bridge neuropsychiatric and metabolic health in addiction medicine.However, their application in AUD remains in the early stage of clinical validation.Critical questions persist
Fields of Study & Subjects
Diabetes Treatment and Management
Bariatric Surgery and Outcomes
Neuropeptides and Animal Physiology
Publication details
- Journal / source
- Addiction
- Publisher
- Wiley
- Volume
- 121
- Issue
- 5
- Pages
- 1033–1035
- Publication date
- 19 February 2026
- Language
- EN