Vulval Lichen Sclerosus Associated With Immune Checkpoint Inhibitor Therapy: A Case Series of 11 Patients

Australasian Journal of Dermatology 2026 Open access

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Authors: Sophie Walter, Francesca Watts, Raquel Ruiz Araujo, Thevaki Wain, Amanda Glanz, Diona Lee Damian, Matteo Salvatore Carlino, Alexander Maxwell Menzies, Georgina Venetia Long, Linda K. Martin
DOI: 10.1111/ajd.70058
Cited by: 0
References: 9

Abstract

There have only been a limited number of case reports that have described vulval lichen sclerosus in patients receiving immune checkpoint inhibitor (ICI) therapy. We describe 11 cases of vulval lichen sclerosus in patients with melanoma treated with ICIs, and in nine of these cases, the lichen sclerosus symptoms began after ICI commencement. This represents the largest reported series to date and highlights the need for clinician awareness of this potential immune-related adverse effect.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Genital Health and Disease Autoimmune Bullous Skin Diseases

Publication details

Journal / source
Australasian Journal of Dermatology
Volume
67
Issue
3
Pages
176–180
Publication date
2 February 2026
Language
EN