Topical Diltiazem in the Management of Cutaneous Leiomyoma–Associated Pain: Evaluation With a Cold‐Provocation Test
Abstract
Cutaneous leiomyomas can cause severe pain that may be spontaneous or stimulus-evoked, and is commonly exacerbated by cold exposure, mechanical pressure/touch, or stress. We report a patient with genetically confirmed hereditary leiomyomatosis and renal cell cancer (HLRCC) in whom topical diltiazem 2% was associated with reduced pain, assessed using a controlled cold-provocation test and validated pain scores. This brief report suggests that topical diltiazem may be a useful symptomatic option and supports further evaluation.
Fields of Study & Subjects
Soft tissue tumors and treatment
Uterine Myomas and Treatments
Neurofibromatosis and Schwannoma Cases
Publication details
- Journal / source
- Australasian Journal of Dermatology
- Volume
- 67
- Issue
- 4
- Pages
- 237–240
- Publication date
- 9 February 2026
- Language
- EN