Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

British Journal of Haematology 2026 Open access

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Authors: Eva Crespo-García, Carlos Quero-Dotor, Aleix Noguera‐Castells, Laia Sancho‐Vila, Laura Martinez‐Verbo, Manel Esteller
DOI: 10.1111/bjh.70339
Cited by: 0
References: 12

Abstract

We show how the loss of activity of the translation initiation factor EIF5A2-either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post-translational modification-induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.

Fields of Study & Subjects

Acute Myeloid Leukemia Research Protein Degradation and Inhibitors Epigenetics and DNA Methylation

Publication details

Journal / source
British Journal of Haematology
Volume
208
Issue
4
Pages
1437–1442
Publication date
28 January 2026
Language
EN