Impact of positive surgical margins on biochemical recurrence and metastases after radical prostatectomy

British Journal of Urology 2026 Open access

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Authors: Joost van Drumpt, D.J.H. Baas, Katja Aben, Arno G.J.L.H. van Leenders, Lambertus Kiemeney, Michiel Sedelaar, Peter Mulders, Jean‐Paul van Basten, Inge van Oort, Berdine L. Heesterman, Diederik M. Somford
DOI: 10.1111/bju.70136
Cited by: 6
References: 36

Abstract

OBJECTIVES: To evaluate the impact of the presence, extent and location of positive surgical margins (PSMs) on the risk of biochemical recurrence (BCR) and metastases in a nationwide cohort of patients who underwent radical prostatectomy (RP) and had 5 years of follow-up. METHODS: All patients diagnosed with prostate cancer in the Netherlands between October 2015 and April 2016 who underwent RP were included in a prospective cohort. Data on these patients from the Netherlands Cancer Registry and the PALGA pathology registry were analysed. BCR was defined as a prostate-specific antigen (PSA) level ≥0.1 ng/mL >28 days after RP. Exclusion criteria were (neo)adjuvant treatment, pN1 disease, and salvage therapy initiated at PSA

Fields of Study & Subjects

Prostate Cancer Diagnosis and Treatment Prostate Cancer Treatment and Research Inflammatory Biomarkers in Disease Prognosis

Publication details

Journal / source
British Journal of Urology
Publisher
Wiley
Volume
138
Issue
S1
Pages
S94–S102
Publication date
13 January 2026
Language
EN