RE : Comments on cIMPACT ‐ NOW Update 11
Abstract
We read with great interest cIMPACT-NOW Update 11, in which the consortium provides diagnostic recommendations for glioblastoma, IDH-wildtype (GBM); diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG); and posterior fossa ependymal tumors.The authors are to be commended for addressing unresolved challenges identified since the release of the 5th edition of the WHO Classification of Tumours of the Central Nervous System (WHO CNS5, 2021).While the update offers valuable guidance, we would like to comment on several aspects that would benefit from clarification, closer alignment with WHO CNS5, and refined wording to avoid diagnostic ambiguity in routine practice.
Fields of Study & Subjects
Glioma Diagnosis and Treatment
Tuberous Sclerosis Complex Research
Advanced Neuroimaging Techniques and Applications
Publication details
- Journal / source
- Brain Pathology
- Volume
- 36
- Issue
- 3
- Pages
- e70061–e70061
- Publication date
- 12 January 2026
- Language
- EN