Immunohistochemistry as a tool for identifying EGFR amplification in CNS tumors

Brain Pathology 2026 Open access

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Authors: Arnault Tauziède‐Espariat, Mary Bah, Farah Sassi, Noémie Pucelle, Charlotte Berthaud, Marion Mandoula, Zeina Dababou, Noah Carnes, Leïla Brissez, Lauren Hasty, Euphrasie Servant, Alice Métais
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DOI: 10.1111/bpa.70073
Cited by: 0
References: 11

Abstract

EGFR gene amplification constitutes a diagnostic hallmark for glioblastoma, IDH-wildtype (GB, IDH-WT). Herein, we demonstrated that EGFR IHC is a highly specific and sensitive biomarker for identifying EGFR amplification and should be part of the neuropathologist's routine panel of antibodies.

Fields of Study & Subjects

Glioma Diagnosis and Treatment Lung Cancer Treatments and Mutations HER2/EGFR in Cancer Research

Publication details

Journal / source
Brain Pathology
Volume
36
Issue
4
Pages
e70073–e70073
Publication date
28 January 2026
Language
EN