GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
Abstract
G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins. Here, we describe the history of the discovery of the members of these two protein families, their structure and GPCR-dependent and -independent functions, as well as the origins of their historic names and the advantages of systematic nomenclature.
Fields of Study & Subjects
Receptor Mechanisms and Signaling
Protein Kinase Regulation and GTPase Signaling
Renin-Angiotensin System Studies
Publication details
- Journal / source
- British Journal of Pharmacology
- Publisher
- Wiley
- Volume
- 183
- Issue
- 11
- Pages
- 2619–2633
- Publication date
- 12 April 2026
- Language
- EN