When Binding Is Not Blockade: Interpreting IgG4 + T Cells After PD ‐1 Therapy

Cancer Science 2026 Open access

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Authors: Man Sun, Dan Zang, Jun Chen
DOI: 10.1111/cas.70379
Cited by: 1
References: 4

Abstract

IgG4 positivity on circulating T cells after PD-1 therapy may indicate residual antibody binding rather than sustained functional PD-1 blockade. During sequential ramucirumab plus docetaxel plus G-CSF treatment, peripheral IgG4+ T-cell dynamics may also be influenced by redistribution and treatment-related confounders, limiting direct inference about effective intratumoral antitumor immunity.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers CAR-T cell therapy research IgG4-Related and Inflammatory Diseases

Publication details

Journal / source
Cancer Science
Publisher
Wiley
Volume
117
Issue
6
Pages
1766–1768
Publication date
9 April 2026
Language
EN