Rectal cancer following radiotherapy for prostate cancer: A propensity‐matched analysis

AIM: Patients who have previously received radiation therapy for primary prostate cancer (PPC) face an elevated risk of developing secondary rectal cancer (SRC). However, the clinical presentation, surgical outcomes, and oncological results of SRC in this context remain poorly characterized. This study aims to compare the clinical and pathological features, as well as treatment outcomes, of patients with primary rectal cancer (PRC) and those with SRC following radiation for prostate cancer. METHODS: Retrospective cohort study using univariate and propensity-matched analyses. Data extracted from electronic medical records at a single tertiary institution [2001-2021]. Male patients with rectal cancer (RC) who underwent oncological resection with or without a prior history of prostate cancer radiation. Patients with a