Timing of seton removal and clinical outcomes in perianal fistulizing Crohn's disease: A systematic review and meta‐analysis

Colorectal Disease 2026

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Authors: Yuki Horio, Motoi Uchino, Yusuke Tomoo, Kazunori Nomura, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Tetsuya Takagawa, Masataka Ikeda, Hiroki Ikeuchi
DOI: 10.1111/codi.70449
Cited by: 1
References: 35

Abstract

BACKGROUND: The optimal timing for seton removal in perianal fistulizing Crohn's disease (PFCD) remains unclear. Therefore, we examined the range of reported timing strategies and their association with clinical outcomes. METHODS: We systematically searched PubMed, Web of Science, Cochrane Library and Ichushi-Web for studies published from January 1990 to June 2025. Eligible studies included adult patients with PFCD who underwent seton placement and reported removal timing and clinical outcomes. Healing and recurrence rates were pooled using a random effects model. Subgroup analyses evaluated seton removal timing ( 80%). Short-term removal (

Fields of Study & Subjects

Anorectal Disease Treatments and Outcomes Inflammatory Bowel Disease Hidradenitis Suppurativa and Treatments

Publication details

Journal / source
Colorectal Disease
Publisher
Wiley
Volume
28
Issue
4
Pages
e70449–e70449
Publication date
1 April 2026
Language
EN