The Role of Liver Biopsy Findings in Uncontrolled Donation After Circulatory Death a 4‐Year Single‐Center Experience

Clinical Transplantation 2026 Open access

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Authors: Luca Novelli, Chiara Lazzeri, Davide Ghinolfi, Manuela Bonizzoli, Tiziana Tatti, Luca Messerini, Giuseppe Feltrin, Adriano Peris
DOI: 10.1111/ctr.70431
Cited by: 2
References: 24

Abstract

BACKGROUND: Uncontrolled donors after circulatory death (uDCDs) are recognized as a potential donor pool. No data are so far available on liver biopsy findings in uDCDs. We aimed at assessing liver biopsy findings in uDCDs consecutively admitted to our Center from 2019 to 2023. METHODS: Twenty nine utilized uDCD consecutively admitted at our Center from 2019 to 2023 were included. Liver biopsies were performed during organ procurement in all uDCDs. RESULTS: The median time from cardiac arrest to normothermic regional perfusion (NRP) run was 144 min, while the median NRP duration was 6 h. The liver was retrieved but not transplanted in 12 donors (12/29, 41%) and transplanted in 10 donors (10/29, 35%). In 7 uDCDs, livers were not retrieved (24%). Ishak grading score 1-2 was observed in most biopsies (21/29, 72%). The incidence of microsteatosis

Fields of Study & Subjects

Organ Transplantation Techniques and Outcomes Liver Disease and Transplantation Organ Donation and Transplantation

Publication details

Journal / source
Clinical Transplantation
Publisher
Wiley
Volume
40
Issue
1
Pages
e70431–e70431
Publication date
1 January 2026
Language
EN