Pharmacokinetics as a Biomarker
Abstract
Pharmacokinetics (PK) has long been differentiated from pharmacodynamics (PD) and biomarkers, yet this distinction undervalues PK's translational relevance. In this Perspective, we propose that PK itself functions as a biomarker that bridges dose, exposure, and response. Using examples from target-mediated drug disposition, antidrug antibodies, cerebrospinal fluid PK, high-dose methotrexate therapy, and anti-infective pharmacology, we illustrate how PK serves as a measurable, predictive, and actionable biomarker that informs drug development, guides decisions, and advances precision medicine.
Fields of Study & Subjects
Monoclonal and Polyclonal Antibodies Research
Multiple Sclerosis Research Studies
Biosimilars and Bioanalytical Methods
Publication details
- Journal / source
- Clinical and Translational Science
- Publisher
- Wiley
- Volume
- 19
- Issue
- 2
- Pages
- e70486–e70486
- Publication date
- 27 January 2026
- Language
- EN