Effects of age and disease duration on the glycaemic outcomes and safety of insulin glargine 300 U/ mL in people with type 2 diabetes in China: A post‐hoc analysis of the INITIATION study

Diabetes Obesity and Metabolism 2026 Open access

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Authors: Liming Chen, Qiu Zhang, Binhong Duan, Xiaohong Wu, Hailong Wan, BINHONG WEN, Jie Han, Haixia Liu, Caixian Yang, Weiwei Liu, Qin Du, Lei Kang
+1 more Minlu Zhang
DOI: 10.1111/dom.70420
Cited by: 0
References: 30

Abstract

AIMS: To evaluate the glycaemic outcomes and safety of insulin glargine 300 U/mL (Gla-300) in Chinese people with uncontrolled type 2 diabetes (T2D) by baseline age and disease duration. MATERIALS AND METHODS: INITIATION was a 24-week, interventional, single-arm study where adults with T2D (glycated haemoglobin [HbA1c] 7.5%-11.0%) received Gla-300. This post-hoc subgroup analysis assessed HbA1c change from baseline to week 24 (primary endpoint), other glycaemic endpoints, insulin dose, hypoglycaemia, body weight change, and treatment satisfaction (using the Diabetes Treatment Satisfaction Questionnaire [DTSQ]) by baseline age (

Fields of Study & Subjects

Diabetes Management and Research Diabetes Treatment and Management Hyperglycemia and glycemic control in critically ill and hospitalized patients

Publication details

Journal / source
Diabetes Obesity and Metabolism
Volume
28
Issue
3
Pages
2255–2264
Publication date
5 January 2026
Language
EN