Elevated triglyceride‐glucose index is associated with increased risk of chronic kidney disease and end‐stage renal disease in type 1 diabetes: Nationwide cohort study

AIMS: Prognostic markers for microvascular complications in type 1 diabetes are needed because factors beyond hyperglycaemia contribute to this risk. The triglyceride-glucose (TyG) index is an established marker of vascular complications in type 2 diabetes; however, its clinical significance in type 1 diabetes remains unknown. We aimed to investigate the association between the TyG index and long-term renal outcomes in a nationwide cohort of adults with type 1 diabetes. MATERIALS AND METHODS: In this nationwide cohort study of 14 782 adults with type 1 diabetes from the Korean National Health Insurance Service database, we used Cox proportional hazards models to evaluate the risk of incident chronic kidney disease (CKD) and end-stage renal disease (ESRD) across quartiles of the baseline TyG index during a median follow-up of 7.04 years. RESULTS: A significant dose-response relationship was observed between the TyG index and adverse renal outcomes. After multivariable adjustment, the highest TyG quartile (Q4) had a 2.15-fold (95% confidence interval, 1.87-2.48) and a 2.90-fold (95% confidence interval, 2.25-3.75) higher risk of developing CKD and ESRD, respectively, than the lowest quartile (Q1) (p for trend