Baseline and 4‐year associations between prediabetes and kidney impairment: Insights from the ILERVAS cohort

Diabetes Obesity and Metabolism 2026 Open access

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Authors: Aitziber Izarra, Marcelino Bermúdez‐López, José Manuel Valdivielso, Reinald Pamplona, G.F. Torres, Dídac Mauricio, Eva Castro‐Boqué, Elvira Fernández, Rafael Simó, C Hernández, Albert Lecube, the ILERVAS project collaborators
DOI: 10.1111/dom.70560
Cited by: 1
References: 47

Abstract

Abstract Aims Prediabetes is a prevalent condition associated with increased cardiovascular and renal risk. However, the long‐term impact of haemoglobin A1c (HbA1c) within the range defined as prediabetes on kidney function remains unclear. This study aimed to evaluate the association between prediabetes and renal function (estimated glomerular filtration rate [eGFR] and albuminuria) through cross‐sectional and prospective analyses over 4 years in a cohort of individuals with no diagnosis of diabetes or established cardiovascular disease. Materials and Methods Analysis using data from 8153 participants in the ILERVAS cohort, a prospective cross‐sectional study. Prediabetes was defined as HbA1c 5.7%–6.4% (ADA criteria). Kidney impairment was defined as eGFR

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Diabetes Cardiovascular Risks and Lipoproteins Diabetes Treatment and Management

Publication details

Journal / source
Diabetes Obesity and Metabolism
Publisher
Wiley
Volume
28
Issue
5
Pages
3777–3787
Publication date
18 February 2026
Language
EN