Response to: Calcitonin gene‐related peptide and headache: Comparison of two commonly used assay kits highlights the perils of measuring neuropeptides with enzyme‐linked immunosorbent assays

Headache The Journal of Head and Face Pain 2026 Open access

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Authors: Alicia Alpuente, Victor José Gallardo, Laila Asskour, Edoardo Caronna, Marta Torres‐Ferrús, Patricia Pozo‐Rosich
DOI: 10.1111/head.70019
Cited by: 0
References: 14

Abstract

equally essential to advance the discipline.Methodological rigor, transparent reporting, awareness of matrix effects, and internal validation remain critical to advancing the field.Salivary CGRP-LI continues to provide valuable insights into migraine pathophysiology and treatment response.By performing comprehensive internal validation in future studies, we aim to further consolidate the utility of this biomarker, while continuing to advocate for greater transparency from kit manufacturers.

Fields of Study & Subjects

Migraine and Headache Studies Neuropeptides and Animal Physiology Pain Mechanisms and Treatments

Publication details

Journal / source
Headache The Journal of Head and Face Pain
Volume
66
Issue
1
Pages
21–23
Publication date
1 January 2026
Language
EN