Advances in cellular therapy for cancer: vector design and genome editing
Abstract
The year 2025 saw continued scientific progress in cell therapy and further commercial expansion of CAR T-cell therapeutics, alongside notable strategic contractions driven largely by manufacturing cost constraints. The field also benefited from the recent transition in T-cell subset nomenclature toward function- and state-based definitions, enabling more precise characterization of CAR T-cell products. We highlight five key advances, including in vivo CAR generation, next-generation genome engineering and the expanding potential of AI-guided antibody discovery platforms for cellular immunotherapy.
Fields of Study & Subjects
CAR-T cell therapy research
CRISPR and Genetic Engineering
Viral Infectious Diseases and Gene Expression in Insects
Publication details
- Journal / source
- Immunology and Cell Biology
- Publisher
- Wiley
- Volume
- 104
- Issue
- 5
- Pages
- 490–493
- Publication date
- 7 April 2026
- Language
- EN