From transcription to biological translation: regulation and recognition of MR1
Abstract
The axis of MR1 restricted T-cell immunity has been an area of growing interest over the past decade. In this "Highlights of 2025" perspective, we discuss recent advances in our understanding of the transcriptional regulation of MR1, the distribution of MR1 protein across tissues and the elucidation of novel MR1 ligands. The advances of 2025 have unlocked new methodologies and mechanistic insights, aiding future studies that consider MR1 and its contribution to the development of MR1-restricted T-cell responses in the context of infection, cancer and autoimmunity.
Fields of Study & Subjects
Immune Cell Function and Interaction
T-cell and B-cell Immunology
Immunotherapy and Immune Responses
Publication details
- Journal / source
- Immunology and Cell Biology
- Publisher
- Wiley
- Volume
- 104
- Issue
- 6
- Pages
- 564–568
- Publication date
- 23 April 2026
- Language
- EN