Origins and drivers of self‐reactive B cells in autoimmune disease
Abstract
Self-reactive B cells are a hallmark of autoimmune disease and may directly contribute to disease pathogenesis. This Research Highlight article reviews four articles published in 2025 that offer new insights into the origins and drivers of self-reactive B cells. These studies investigate self-reactive B cells in human peripheral blood, murine models, and the role of viral and genetic drivers.
Fields of Study & Subjects
Diabetes and associated disorders
T-cell and B-cell Immunology
Systemic Lupus Erythematosus Research
Publication details
- Journal / source
- Immunology and Cell Biology
- Publisher
- Wiley
- Volume
- 104
- Issue
- 6
- Pages
- 578–581
- Publication date
- 1 May 2026
- Language
- EN