Comment on: Pasco ST Et Al. “Challenge‐Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory”
Abstract
This schematic illustrates the role of endoplasmic reticulum (ER) stress and PERK inhibition in modulating pancreatic cancer cell fate. ER stress activates the PERK pathway, which contributes to tumor cell survival. Pharmacologic inhibition of PERK, as depicted, leads to two downstream effects: decreased cellular proliferation and increased apoptosis. The diagram highlights the therapeutic potential of PERK-targeting strategies in disrupting cancer cell growth and promoting programmed cell death.
Fields of Study & Subjects
Endoplasmic Reticulum Stress and Disease
Immunotherapy and Immune Responses
Immune responses and vaccinations
Publication details
- Journal / source
- Immunology
- Volume
- 177
- Issue
- 4
- Pages
- 641–642
- Publication date
- 2 February 2026
- Language
- EN