Metabolic Stress and Immune Activation in Heart Failure With a Preserved Ejection Fraction

Immunological Reviews 2026 Open access

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Authors: Ana Pereira, Santiago Alvarez‐Argote, Isaac Meite, Hiroyasu Inui, Jacob Sterling, Evette J. Thorp, Evette J. Thorp, Matthew J. Feinstein, Mallory Filipp, Edward B. Thorp, Edward B. Thorp
DOI: 10.1111/imr.70103
Cited by: 3
References: 100

Abstract

Inflammation is triggered by imbalances to systemic and cellular metabolism. This occurs in the setting of cardiometabolic heart failure, for which low-grade inflammation is a commonly reported feature. In experimental models, immune cells are causal determinants in the pathophysiology of metabolic syndromes. Herein we discuss evidence for the contribution of metabolic stress to immune cell activation during cardiometabolic heart failure with preserved ejection fraction. We also discuss related therapeutic approaches along the way.

Fields of Study & Subjects

Cardiac Fibrosis and Remodeling Cardiovascular Function and Risk Factors Adipokines Inflammation and Metabolic Diseases

Publication details

Journal / source
Immunological Reviews
Publisher
Wiley
Volume
337
Issue
1
Pages
e70103–e70103
Publication date
1 January 2026
Language
EN