Inflammation and Immunogenetics in Cardiomyopathies: From Molecular Mechanisms to Therapeutic Perspectives
Abstract
Genetic variants that impair cardiac function or predispose individuals to autoimmune diseases can influence both the risk and severity of inflammatory heart diseases, including lymphocytic myocarditis and cardiac sarcoidosis. We review recent clinical and experimental studies that describe the emerging interplay between genetic susceptibility and active myocardial inflammation. We summarize the current perspective on the mechanisms of inflammatory pathways and gene-immune interactions, and explore the emerging therapeutic approaches aimed at targeting inflammation in genetic cardiomyopathies.
Fields of Study & Subjects
Viral Infections and Immunology Research
Eosinophilic Disorders and Syndromes
Sarcoidosis and Beryllium Toxicity Research
Publication details
- Journal / source
- Immunological Reviews
- Publisher
- Wiley
- Volume
- 338
- Issue
- 1
- Pages
- e70105–e70105
- Publication date
- 1 February 2026
- Language
- EN