Regarding: ‘The Role of EphrinB2 – EphB4 Signalling Pathway in Regeneration of Inflammatory Bone Defect’

Journal of Cellular and Molecular Medicine 2026 Open access

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Authors: Yue Feng, Yantao Zhao
DOI: 10.1111/jcmm.71031
Cited by: 0
References: 6

Abstract

The recent study by Shen et al., 'The Role of EphrinB2-EphB4 Signalling Pathway in Regeneration of Inflammatory Bone Defect', provides valuable experimental evidence linking the EphrinB2-EphB4 axis to bone regeneration under inflammatory conditions [1].Using a TNF-α-induced mandibular defect model, the authors elegantly demonstrated that suppression of EphB4 signalling attenuates osteogenic differentiation while promoting osteoclast activity, resulting in impaired bone repair.This work highlights the central role of bidirectional Eph-ephrin communication in maintaining the delicate balance between osteoblast and osteoclast function essential for skeletal homeostasis [2, 3].

Fields of Study & Subjects

Bone Metabolism and Diseases Axon Guidance and Neuronal Signaling Medicinal Plant Pharmacodynamics Research

Publication details

Journal / source
Journal of Cellular and Molecular Medicine
Volume
30
Issue
2
Pages
e71031–e71031
Publication date
1 January 2026
Language
EN