SWI / SNF Chromatin Remodelling Complex in Hepatic Physiology: Mechanistic Insights Into Development, Homeostasis and Pathogenesis

The liver executes essential metabolic functions including energy homeostasis, lipid biosynthesis, cholesterol regulation and xenobiotic detoxification. While hepatocyte metabolic activity forms the foundation of these processes, their precise regulation is achieved through chromatin remodelling mechanisms, with the SWI/SNF complex emerging as a central epigenetic orchestrator. Accumulating evidence positions this ATP-dependent chromatin remodeler as a critical regulator of hepatic development, homeostatic maintenance and pathological transformation. Through nucleosome repositioning and histone-DNA interaction modulation, the SWI/SNF complex governs transcriptional programs controlling cellular proliferation, differentiation and metabolic adaptation. This review synthesises current understanding of SWI/SNF-mediated epigenetic regulation in hepatic biology and explores its therapeutic potential for liver disorders.