Effect of switching from intermittently scanned continuous glucose monitoring to FreeStyle Libre 2 with real‐time continuous glucose monitoring and alert functionality

AIMS/INTRODUCTION: This study aimed to assess the impact of switching from FreeStyle Libre (FSL) to FreeStyle Libre 2 (FSL2) with real-time continuous glucose monitoring (rtCGM) functionality. MATERIALS AND METHODS: We retrospectively assessed 58 patients who transitioned from FSL to FSL2 with rtCGM functionality. RESULTS: Switching from FSL to FSL2 significantly increased the valid data acquisition rate (76.8% ± 21.6% vs 90.4% ± 18.0%, P < 0.001). Time in range (TIR) improved from 57.7% ± 18.1% to 61.7% ± 17.1% (P = 0.023); time in tight range improved from 33.3% ± 15.4% to 38.6% ± 16.9% (P = 0.006), and glycated hemoglobin decreased from 7.6% ± 1.1% to 7.4% ± 1.0% (P = 0.009). TIR improvement was immediate in Type 1 diabetes but gradual after an initial decline in Type 2 diabetes. Logistic regression identified younger age as a predictor of TIR improvement (odds ratio: 0.95, 95% confidence interval: 0.90-0.99, P = 0.034). CONCLUSIONS: Transitioning from FSL to FSL2 with rtCGM functionality improved valid data acquisition rate and glycemic control, particularly in patients with Type 1 diabetes. The duration required for improvement in continuous glucose monitoring-related parameters varied by diabetes type, with early improvements observed in Type 1 diabetes and gradual improvements in Type 2 diabetes.