Association between thyroid dysfunction and cognitive impairment in type 2 diabetes mellitus: A cross‐sectional study
Abstract
OBJECTIVE: To investigate the association between thyroid dysfunction and cognitive impairment in patients with type 2 diabetes mellitus (T2DM). METHODS: In this cross-sectional study, 486 adult T2DM patients between January 2022 and January 2024 were enrolled. General clinical data and laboratory parameters [glycated hemoglobin (HbA1c), thyroid-stimulating hormone (TSH), free thyroxine (FT4)] were collected. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA 0.05). CONCLUSION: Hypothyroidism is an independent risk factor for cognitive impairment in T2DM patients, with a progressive risk increase associated with higher TSH levels. These findings underscore the importance of integrating thyroid function evaluation into the cognitive assessment and management strategy for this patient population.
Fields of Study & Subjects
Thyroid Disorders and Treatments
Thyroid Cancer Diagnosis and Treatment
Ophthalmology and Eye Disorders
Publication details
- Journal / source
- Journal of Diabetes Investigation
- Publisher
- Wiley
- Volume
- 17
- Issue
- 6
- Pages
- 1034–1042
- Publication date
- 2 April 2026
- Language
- EN