Lipid‐Based Nanoparticles for Time‐Release Delivery of Flavonoids

ABSTRACT This study aimed to explore various types of lipid nanoparticles used as carriers for flavonoids, emphasizing encapsulation mechanisms, physicochemical stability, controlled release efficiency, and their therapeutic potential in diverse clinical and nutritional contexts. An integrative literature review was conducted, focusing on lipid‐based nanoparticles employed for flavonoid delivery, emphasizing the encapsulation of these bioactive compounds. The results indicate that nanotechnology, particularly lipid carriers (NLCs), enhances encapsulation efficiency, physicochemical stability, and bioavailability of flavonoids, especially quercetin. NLC‐based formulations have an encapsulation efficiency of up to 97%, demonstrating their superior performance in controlled release and protection against compound degradation. Furthermore, the nanoparticle preparation method significantly influences their final characteristics, with hot emulsification and ionic gelation being the most frequently employed techniques. The data also support antioxidant, anti‐inflammatory, neuroprotective, and photoprotective applications, thus expanding in pharmaceutical, cosmetic, and functional food products.