Potential Risks of Blocking GDF15 ‐Based Brain Energy Sensing
Abstract
GDF15 signals energetic stress to the brain, leading to unpleasant symptoms as the body conserves and reallocates energy. In conditions such as frailty and cancer, suppression of GDF15 signaling is expected to lead to an improvement in symptoms, but potentially at the cost of long-term health and survival.
Fields of Study & Subjects
GDF15 and Related Biomarkers
Muscle Physiology and Disorders
Genetics
Aging
and Longevity in Model Organisms
Publication details
- Journal / source
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Volume
- 74
- Issue
- 5
- Pages
- 1516–1519
- Publication date
- 16 March 2026
- Language
- EN