Optimization of a hypercompact Fanzor2 system for improved genome editing performance in plants

Journal of Integrative Plant Biology 2026 Open access

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Authors: Xingyu Cao, Hongfei Liu, Shasha Bai, Rui Wang, Lanqin Xia, Yongwei Sun
DOI: 10.1111/jipb.70346
Cited by: 1
References: 8

Abstract

Native Fanzor2 nucleases exhibit weak editing activity in plants. An optimized Fanzor2 system engineered via ωRNA optimization and structure-based protein mutagenesis achieves robust editing at recalcitrant genomic sites and enables cytosine base editing, supporting versatile crop genome modification via transformation or viral delivery.

Fields of Study & Subjects

CRISPR and Genetic Engineering RNA regulation and disease Virus-based gene therapy research

Publication details

Journal / source
Journal of Integrative Plant Biology
Publisher
Wiley
Volume
68
Issue
9
Pages
3190–3192
Publication date
14 July 2026
Language
EN