Validation of AURA ‐W: An AI ‐Driven 3D Imaging System Metrics for Objective Wrinkle Assessment After Botulinum Toxin Treatment

ABSTRACT Background Most clinical assessments of botulinum toxin rely on subjective observation, limiting reproducibility. The Aura 3D Imaging System combines high‐resolution photogrammetry imaging with AI analysis to provide standardized wrinkle measurements. Objective Validate the Aura 3D Imaging System and the AURA‐W scale as an objective tool for assessing wrinkle reduction for botulinum toxin treatment. Methods Standardized 3D captures were obtained before treatment and at follow‐up (about 27 days after) for 100 participants. Letibotulinum Toxin A was injected into the glabellar, forehead, and periorbital regions. The AURA‐W was used to quantify wrinkle severity across facial regions. Results Wrinkle scores decreased consistently after treatment, with the greatest improvements in the upper face. Periocular changes were smaller but still evident. Conclusion The AURA‐W enables objective, reproducible assessment of wrinkle reduction following botulinum toxin therapy. By integrating 3D imaging with AI analysis, it overcomes limitations of subjective scales and enhances precision in both clinical evaluation and research.