Extracellular Vesicles in Gingival Crevicular Fluid as Indicators of Periodontitis and Early Response to Non‐surgical Periodontal Therapy

Journal of Periodontal Research 2026 Open access

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Authors: Pingping Han, Andrew Liaw, Akila Suboda Vithanage, Carlos F. Salomon, Sašo Ivanovski
DOI: 10.1111/jre.70070
Cited by: 1
References: 10

Abstract

Our study aims to profile EV subtypes and cytokines (IL-4, IL-10, IL-1β, TNF-α) across (1) shallow pockets (≤ 3 mm) in healthy, gingivitis, and periodontitis patients, and (2) deep pockets (≥ 6 mm) in periodontitis patients before and 1 month after NSPT. Preliminary data suggest that sEV-IL-4 and CD9+ sEV may reflect treatment response in periodontitis, being elevated in responding versus nonresponding sites.

Fields of Study & Subjects

Oral microbiology and periodontitis research Extracellular vesicles in disease Bone and Dental Protein Studies

Publication details

Journal / source
Journal of Periodontal Research
Publisher
Wiley
Volume
61
Issue
4
Pages
421–423
Publication date
21 January 2026
Language
EN