A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

Journal of Small Animal Practice 2026 Open access

Read full text
Authors: Katrina L. Mealey
DOI: 10.1111/jsap.70098
Cited by: 0
References: 11

Abstract

This mini-review describes the pathophysiology of the disrupted hypothalamic-pituitary-adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1-1Δ in dogs and ABCB11930-1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.

Fields of Study & Subjects

Adrenal Hormones and Disorders Veterinary Medicine and Surgery Drug Transport and Resistance Mechanisms

Publication details

Journal / source
Journal of Small Animal Practice
Volume
67
Issue
6
Pages
487–491
Publication date
3 February 2026
Language
EN