Serial measurement of serum pancreatic lipase immunoreactivity and trypsin‐like immunoreactivity concentrations in dogs and cats with diabetes mellitus

OBJECTIVES: To serially evaluate the serum pancreatic lipase and trypsin-like immunoreactivity concentrations in dogs and cats with diabetes mellitus. MATERIALS AND METHODS: Serum pancreatic lipase and trypsin-like immunoreactivity concentrations, specific for each species, were measured in surplus serum samples from 52 dogs and 19 cats previously diagnosed with diabetes mellitus. The samples were collected at initial presentation and at re-examinations. RESULTS: Serum pancreatic lipase concentrations were indicative of pancreatitis (>400 μg/L in dogs and >8.8 μg/L in cats) in 16/52 (31%) dogs and 5/19 (26%) cats with diabetes mellitus at initial presentation, respectively, and in 22/52 (42%) dogs and 7/19 (37%) cats at least at one re-examination, respectively. Serum trypsin-like immunoreactivity concentration was indicative of exocrine pancreatic insufficiency (≤5.5 μg/L) in 2/52 (4%) dogs at initial presentation and in 3/52 (6%) dogs at least at one re-examination. Serum trypsin-like immunoreactivity concentration was indicative of exocrine pancreatic insufficiency (