SCCA2 as a biomarker reflecting patient‐reported disease burden in children with mild atopic dermatitis under maintenance therapy

BACKGROUND: In mild atopic dermatitis (AD), evaluating disease activity during maintenance therapy is challenging due to subtle clinical signs. Serum squamous cell carcinoma antigen 2 (SCCA2) has been proposed as a sensitive biomarker, but its utility in assessing disease status specifically in mild AD remains unclear. OBJECTIVE: To assess the utility of serum SCCA2 in children with mild AD receiving maintenance therapy, focusing on its relationship with patient-reported outcomes. Serum thymus and activation-regulated chemokine (TARC), an established marker, was analyzed as a comparator. METHODS: Sixty-nine pediatric patients with mild AD were enrolled. Clinical severity was assessed by the Eczema Area and Severity Index (EASI; physician-rated) and the Patient-Oriented Eczema Measure (POEM; patient-reported). Baseline serum SCCA2 and TARC were measured. Associations were first examined using Spearman's rank correlation. Temporal associations between baseline SCCA2 and POEM at Days 3 and 7 were further evaluated using linear mixed-effects models, and complementary bootstrap resampling and Steiger's Z test were applied for correlation comparisons. RESULTS: Although all patients were classified as mild by EASI, POEM scores ranged widely, indicating discordance between physician- and patient-assessed severity. SCCA2, but not TARC, was significantly correlated with POEM scores at baseline. The correlation between baseline SCCA2 and POEM was strongest on Day 3 and attenuated by Day 7. Linear mixed-effects modeling confirmed a significant time-dependent association. CONCLUSION: SCCA2 reflects patient-experienced symptom burden more closely than physician-assessed severity in mild AD. Its short-term, time-dependent association with POEM suggests potential utility for identifying early or imminent symptom burden.