Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia

Psychiatry and Clinical Neurosciences 2026 Open access

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Authors: Youta Torii, Hirotaka Sekiguchi, Chikako Habuchi, Ayako Miwa, Shusei Arafuka, Kazuhiro Takeda, Hiroshige Fujishiro, Mari Yoshida, Yasushi Iwasaki, Shuji Iritani, Masashi Ikeda
DOI: 10.1111/pcn.70079
Cited by: 1
References: 69

Abstract

AIM: Lateral ventricular enlargement is a robust morphological finding in schizophrenia. However, its characteristics and neuropathological basis in elderly patients remain poorly understood. We aimed to clarify the impact of neuropathologically confirmed neurodegenerative pathologies on lateral ventricular size in elderly patients with schizophrenia and explore other clinical factors potentially influencing ventricular morphology. METHODS: We examined 31 postmortem brains from patients with schizophrenia with an onset age of

Fields of Study & Subjects

Schizophrenia research and treatment Advanced Neuroimaging Techniques and Applications Mental Health and Psychiatry

Publication details

Journal / source
Psychiatry and Clinical Neurosciences
Publisher
Wiley
Volume
80
Issue
8
Pages
682–693
Publication date
28 May 2026
Language
EN