Neonatal Herpes Simplex Infection With Extensive Congenital Epidermal Skin Loss: A Report of Four Cases

Pediatric Dermatology 2026 Open access

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Authors: Niamh Theresa McSwiney, Emily Vaughan, Alexandra Phillips, L. Newell, Hannah Wainman, Pablo Lopez Balboa, Anna E. Martinez, S. P. Wardle, Jane Ravenscroft
DOI: 10.1111/pde.70144
Cited by: 0
References: 13

Abstract

We describe four cases of neonatal epidermal skin loss presenting at birth, secondary to disseminated herpes simplex virus (HSV) infection. In three, there was a strikingly similar presentation of 80% epidermal skin loss with sparing of the hands, feet, and areas on either the face or scalp. In the fourth neonate, the skin loss was less extensive but followed a similar pattern. This case series highlights an under-recognized pattern of skin involvement in systemic neonatal HSV, and the importance of early recognition and optimal management to improve outcomes.

Fields of Study & Subjects

Herpesvirus Infections and Treatments Genetic and rare skin diseases. Neonatal and Maternal Infections

Publication details

Journal / source
Pediatric Dermatology
Volume
43
Issue
3
Pages
734–737
Publication date
11 February 2026
Language
EN