Setmelanotide in Bardet‐Biedl Syndrome: A Case Report
Abstract
Setmelanotide is a melanocortin-4-receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet-Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication. Herein is a review of the literature for other potential side effects that warrant regular dermatologic screening, including alteration of existing melanocytic lesions. Exact screening guidelines have not been completely defined, though it is recommended that patients receive baseline and annual examinations while undergoing treatment with this agent.
Fields of Study & Subjects
Genetic and Kidney Cyst Diseases
Hedgehog Signaling Pathway Studies
Genetic Syndromes and Imprinting
Publication details
- Journal / source
- Pediatric Dermatology
- Publisher
- Wiley
- Volume
- 43
- Issue
- 5
- Pages
- 1196-1199
- Publication date
- 17 April 2026
- Language
- EN