Establishment of a Patient‐Derived Xenograft Model of a Testicular Yolk Sac Tumor

Pathology International 2026 Open access

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Authors: Nobuhiko Shimizu, Taku Naiki, Aya Naiki‐Ito, Yosuke Sugiyama, Takashi Nagai, Toshiki Etani, Toshiharu Morikawa, Masakazu Gonda, Maria Aoki, Daiki Ishikawa, Yukihiro Umemoto, Satoru Takahashi
+1 more Takahiro Yasui
DOI: 10.1111/pin.70079
Cited by: 0
References: 5

Abstract

We have established a highly stable and reproducible patient derived xenograft model that exclusively and robustly retains the morphological, functional, and proliferative characteristics of human yolk sac tumor of the testis. This model might provide an invaluable in vivo platform for accelerating the discovery and validation of novel therapeutic strategies for this aggressive malignancy, with the ultimate aim of improving the prognosis for affected patients.

Fields of Study & Subjects

Testicular diseases and treatments Sperm and Testicular Function Sarcoma Diagnosis and Treatment

Publication details

Journal / source
Pathology International
Volume
76
Issue
3
Pages
e70079–e70079
Publication date
4 January 2026
Language
EN