Involucrum Formation Leading to Healing in Stage 3 Medication‐Related Osteonecrosis of the Jaws
Abstract
INTRODUCTION: An involucrum refers to the formation of new bone by the periosteum surrounding a bony sequestrum. Over time, the sequestrum undergoes resorption via creeping substitution, ultimately leading to complete bone healing. This phenomenon is well-documented in the context of long bone osteomyelitis. METHOD: We report a case of an 82-year-old woman who healed spontaneously from stage 3 medication-related osteonecrosis of the jaw following dentoalveolar surgery while on denosumab. AIM: The aim of this article is to highlight a rare instance of resolution through the process of involucrum, demonstrating its potential role in the natural healing of MRONJ.
Fields of Study & Subjects
Bone health and treatments
Osteomyelitis and Bone Disorders Research
Oral health in cancer treatment
Publication details
- Journal / source
- Special Care in Dentistry
- Publisher
- Wiley
- Volume
- 46
- Issue
- 3
- Pages
- e70184–e70184
- Publication date
- 1 May 2026
- Language
- EN