Hepatitis B virus infection with high HBsAg and undetectable DNA levels in untreated blood donors: Viral mechanisms and transfusion safety implications

Transfusion 2026 Open access

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Authors: Maelenn Pailine Delcourt, Marion Vermeulen, Aneta Kopacz, Manuela Miletić, Andrew Saville, Christoph Niederhauser, Jean–Michel Pawlotsky, Syria Laperche, Daniel Candotti
DOI: 10.1111/trf.70334
Cited by: 1
References: 37

Abstract

BACKGROUND: Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear. STUDY DESIGN AND METHODS: Seventy-five blood donors with HBsAg >100 IU/mL and undetectable or very low HBV DNA (

Fields of Study & Subjects

Hepatitis B Virus Studies Organ Transplantation Techniques and Outcomes HIV Research and Treatment

Publication details

Journal / source
Transfusion
Publisher
Wiley
Volume
66
Issue
10
Pages
1993-2006
Publication date
20 July 2026
Language
EN