Modulation of slow and fast oscillations by direct current stimulation in the cerebral cortex in vitro
Abstract
Non-invasive brain stimulation techniques, such as transcranial direct current stimulation, are used in the treatment of neurological disorders. However, the mechanisms by which electric fields modulate cortical network activity are only partially understood. Our aim was to determine the modulation of spontaneous cortical activity by static electric fields and their underlying network mechanisms, which we investigated in vitro and in silico. Neocortical slices were exposed to constant fields of varying intensities and directions. We measured their effect on slow oscillations (SOs,
Fields of Study & Subjects
Transcranial Magnetic Stimulation Studies
Neural dynamics and brain function
Neurological disorders and treatments
Publication details
- Journal / source
- The Journal of Physiology
- Publisher
- Wiley
- Volume
- 604
- Issue
- 5
- Pages
- 2131–2151
- Publication date
- 11 February 2026
- Language
- EN