Ultrasonographic vascular indices in the post-evacuation assessment of complete hydatidiform mole and gestational trophoblastic neoplasia

AIM: To identify clinical, biochemical, and ultrasonographic parameters that may serve as early predictors of gestational trophoblastic neoplasia (GTN) in patients initially diagnosed with complete hydatidiform mole (CHM). MATERIAL AND METHODS: This retrospective study included 47 patients with trophoblastic gestational disease, of whom 28 had CHM and 19 developed GTN. Clinical data, serum human chorionic gonadotropin (hCG) levels, and ultrasonographic parameters-including vascular index (VI) (MV-Flow®) and uterine artery pulsatility index (PI)-were collected and analyzed. Logistic regression and receiver operating characteristic (ROC) curve analyses were used to assess predictive value. RESULTS: GTN patients had significantly higher rates of second uterine evacuation (47.4% vs. 7.1%, p=0.001), prolonged time to hCG normalization (92.0 vs. 40.0 days, p