Clinical optoretinography for evaluating photoreceptor disease

Optoretinography (ORG) is an emerging method for parallel structural and functional assessment of the retina. Originally demonstrated using high-resolution and high-speed OCT systems, ORG has recently been implemented with clinical-grade OCT. Here we show that clinical-grade ORG is capable of measuring light-evoked photoreceptor responses in subjects without retinal disease, and also capable of revealing alterations in the photoreceptor responses of patients with inherited retinal disease, unexplained vision loss, and vitamin A deficiency.