Correlating non-invasive multiphoton imaging with spatial transcriptomics in a clinical study of atopic dermatitis

Photonics in Dermatology and Plastic Surgery 2026

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Authors: Conor L. Evans, Yuxiao Wei, SUMMAIYYA AHMED, Sojourner Rouco-Crenshaw, Yakir S. Levin, Lilit Garibyan, Chifei Sun, Erika Boarder, Justine Carl, Heather Bullins, Angelina Volkova, Leandro Santos
+6 more Wonsang Hwang, Jackson Riseman, Jindou Shi, Stephen A. Boppart, Cynthia Dawn Timmers, Susan Smith
DOI: 10.1117/12.3079352
Cited by: 0

Abstract

Atopic dermatitis is a common disease that afflicts millions but is still diagnosed and treated in many cases by scoring and treatment by trial-and-error. We carried out a clinical study employing non-invasive multiphoton microscopy alongside spatial transcriptomic analysis with the goal of correlating in vivo imaging spatial parameters with gene expression analysis. The study found numerous strong correlations and tantalizingly demonstrated non-invasive multiphoton imaging capable of predicting spatial transcriptomic alterations.

Fields of Study & Subjects

Dermatology and Skin Diseases Advanced Fluorescence Microscopy Techniques Single-cell and spatial transcriptomics

Publication details

Journal / source
Photonics in Dermatology and Plastic Surgery
Pages
7–7
Publication date
4 March 2026
Language
EN