Corneal stiffness measurements in non-human primates with experimental glaucoma using optical coherence elastography

Glaucoma is a major cause of irreversible blindness, which is primarily associated with progressive optic nerve damage. In experimental models of glaucoma, sustained elevation of intraocular pressure (IOP) has been associated with structural remodeling of load-bearing ocular tissues, including the cornea, resulting in increased stiffness and reduced thickness. In the present study, we used OCE to measure corneal stiffness in a rhesus macaque model (N=2) where ocular hypertension was induced in one eye and the other eye served as a control. A significant (p